Engineered virus platform

Oncolytic virus engineering and production

FuBio engineers and produces oncolytic viruses across four platforms. Work typically starts from a tumor-selective backbone, then adds a transgene payload or a capsid modification to steer selectivity and potency. All material is supplied for research and preclinical evaluation only.

Request a Quote Catalog Products

  • Four virus platforms

    Oncolytic adenovirus, Newcastle disease virus, herpes simplex virus and vesicular stomatitis virus.

  • Armed constructs

    Payloads such as GM-CSF, ADP and RGD-modified capsids are available in catalog constructs.

  • Tracking reporters

    EGFP, mCherry and other fluorescent reporters support replication and biodistribution tracking.

Capabilities

  • Backbone design

    Deletion and promoter strategies that restrict replication to tumor cells, including hTERT-driven E1A/E1B designs.

  • Payload insertion

    Immunomodulatory and cytotoxic payloads cloned into permissive loci with sequence verification.

  • Capsid and surface modification

    RGD and similar motifs introduced to alter tropism and improve delivery to target cells.

  • Propagation and release

    Amplification in permissive producer systems with titer determination and contamination testing.

Platforms in this line

  • Oncolytic adenovirus

    Oncolytic adenoviruses are the most widely used oncolytic platform. FuBio supplies adenoviral constructs with tumor-selective promoter control and...

    • Tumor cell selectivity and cytotoxicity studies
    • Oncolytic virus and immunotherapy combination research
    • Payload efficacy comparison in preclinical models

    13 catalog products

  • Newcastle disease virus

    Newcastle disease virus replicates preferentially in tumor cells and has a strong record as an oncolytic and immunostimulatory agent in research...

    • Oncolytic virus efficacy screening
    • Innate immune response research
    • Combination studies with immune checkpoint research tools

    1 catalog products

  • Herpes simplex virus

    Herpes simplex virus type 1 offers a large genome and a well-characterized replication cycle, which makes it suitable for oncolytic and gene delivery...

    • Oncolytic HSV-1 mechanism of action studies
    • Immune activation and payload comparison
    • Neuronal gene delivery research

    1 catalog products

  • Vesicular stomatitis virus

    Vesicular stomatitis virus is a fast-replicating, cytoplasmically replicating vector widely used to study oncolytic activity and antiviral immunity...

    • Interferon response and innate immunity research
    • Oncolytic activity screening
    • Viral replication kinetics studies

    1 catalog products

Need a specification or a quotation?

Send the vector, payload and scale you need. We reply with feasibility, lead time and price within one business day.

Request a Quote