Engineered virus platform

Vesicular stomatitis virus

Vesicular stomatitis virus is a fast-replicating, cytoplasmically replicating vector widely used to study oncolytic activity and antiviral immunity. Matrix protein modifications tune the interferon response to the research question.

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  • Matrix protein variants

    M51R-type modification attenuates the interferon-blocking function for immune studies.

  • Reporter genes

    GFP-carrying VSV for tracking replication and spread.

  • Rapid replication

    Short replication cycle, useful for time-resolved experiments.

  • Broad cell tropism

    Infects a wide range of mammalian cell lines without a specific receptor requirement.

Typical applications

  • Interferon response and innate immunity research
  • Oncolytic activity screening
  • Viral replication kinetics studies
  • Reporter-based tracking of infection

Specifications

Catalog constructs
Reporter and matrix-variant VSV available
Volume
1 mL
Titer
1E+8 TCID50/mL for the reporter construct
Custom engineering
Payload insertion on request

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